Ontology highlight
ABSTRACT:
SUBMITTER: Thaci B
PROVIDER: S-EPMC4165413 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Thaci Bart B Brown Christine E CE Binello Emanuela E Werbaneth Katherine K Sampath Prakash P Sengupta Sadhak S
Neuro-oncology 20140410 10
Glioblastoma multiforme (GBM) remains one of the most lethal primary brain tumors despite surgical and therapeutic advancements. Targeted therapies of neoplastic diseases, including GBM, have received a great deal of interest in recent years. A highly studied target of GBM is interleukin-13 receptor α chain variant 2 (IL13Rα2). Targeted therapies against IL13Rα2 in GBM include fusion chimera proteins of IL-13 and bacterial toxins, nanoparticles, and oncolytic viruses. In addition, immunotherapie ...[more]