Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC4165609 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Li Qiyuan Q Seo Ji-Heui JH Stranger Barbara B McKenna Aaron A Pe'er Itsik I Laframboise Thomas T Brown Myles M Tyekucheva Svitlana S Freedman Matthew L ML
Cell 20130101 3
Germline determinants of gene expression in tumors are infrequently studied due to the complexity of transcript regulation caused by somatically acquired alterations. We performed expression quantitative trait locus (eQTL)-based analyses using the multi-level information provided in The Cancer Genome Atlas (TCGA). Of the factors we measured, cis-acting eQTLs accounted for 1.2% of the total variation of tumor gene expression, while somatic copy-number alteration and CpG methylation accounted for ...[more]