Ontology highlight
ABSTRACT:
SUBMITTER: Wang SH
PROVIDER: S-EPMC4166160 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Wang Shih-Hsiu J SH Celic Ivana I Choi Se-Young SY Riccomagno Martin M Wang Qiang Q Sun Lu O LO Mitchell Sarah P SP Vasioukhin Valera V Huganir Richard L RL Kolodkin Alex L AL
The Journal of neuroscience : the official journal of the Society for Neuroscience 20140901 38
Most excitatory synapses in the mammalian brain are formed on dendritic spines, and spine density has a profound impact on synaptic transmission, integration, and plasticity. Membrane-associated guanylate kinase (MAGUK) proteins are intracellular scaffolding proteins with well established roles in synapse function. However, whether MAGUK proteins are required for the formation of dendritic spines in vivo is unclear. We isolated a novel disc large-5 (Dlg5) allele in mice, Dlg5(LP), which harbors ...[more]