Identification and validation of T-cell epitopes in outer membrane protein (OMP) of Salmonella typhi.

ABSTRACT: This study aims to design epitope-based peptides for the utility of vaccine development by targeting outer membrane protein F (Omp F), because two available licensed vaccines, live oral Ty21a and injectable polysaccharide, are 50% to 80% protective with a higher rate of side effects. Conventional vaccines take longer time for development and have less differentiation power between vaccinated and infected cells. On the other hand, Peptide-based vaccines present few advantages over other vaccines, such as stability of peptide, ease to manufacture, better storage, avoidance of infectious agents during manufacture, and different molecules can be linked with peptides to enhance their immunogenicity. Omp F is highly conserved and facilitates attachment and fusion of Salmonella typhi with host ce

SUBMITTER: Tanu AR 

PROVIDER: S-EPMC4166765 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature