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Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders.


ABSTRACT: Peptides synthesized in endocrine cells in the gastrointestinal tract and neurons are traditionally considered regulators of metabolism, energy intake, and appetite. However, recent work has demonstrated that many of these peptides act on corticostriatal-limbic circuitry and, in turn, regulate addictive behaviors. Given that alcohol is a source of energy and an addictive substance, it is not surprising that increasing evidence supports a role for gut-brain peptides specifically in alcohol use disorders (AUD). In this review, we discuss the effects of several gut-brain peptides on alcohol-related behaviors and the potential mechanisms by which these gut-brain peptides may interfere with alcohol-induced changes in corticostriatal-limbic circuitry. This review provides a summary of current knowledge on gut-brain peptides focusing on five peptides: neurotensin, glucagon-like peptide 1, ghrelin, substance P, and neuropeptide Y. Our review will be helpful to develop novel therapeutic targets for AUD.

SUBMITTER: Vadnie CA 

PROVIDER: S-EPMC4166902 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders.

Vadnie Chelsea A CA   Park Jun Hyun JH   Abdel Gawad Noha N   Ho Ada Man Choi AM   Hinton David J DJ   Choi Doo-Sup DS  

Frontiers in neuroscience 20140918


Peptides synthesized in endocrine cells in the gastrointestinal tract and neurons are traditionally considered regulators of metabolism, energy intake, and appetite. However, recent work has demonstrated that many of these peptides act on corticostriatal-limbic circuitry and, in turn, regulate addictive behaviors. Given that alcohol is a source of energy and an addictive substance, it is not surprising that increasing evidence supports a role for gut-brain peptides specifically in alcohol use di  ...[more]

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