Ontology highlight
ABSTRACT:
SUBMITTER: Chiu GS
PROVIDER: S-EPMC4167209 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Chiu Gabriel S GS Darmody Patrick T PT Walsh John P JP Moon Morgan L ML Kwakwa Kristin A KA Bray Julie K JK McCusker Robert H RH Freund Gregory G GG
Brain, behavior, and immunity 20140604
Anxiety is one of the most commonly reported psychiatric conditions, but its pathogenesis is poorly understood. Ailments associated with activation of the innate immune system, however, are increasingly linked to anxiety disorders. In adult male mice, we found that adenosine doubled caspase-1 activity in brain by a pathway reliant on ATP-sensitive potassium (KATP) channels, protein kinase A (PKA) and the A2A adenosine receptor (AR). In addition, adenosine-dependent activation of caspase-1 increa ...[more]