Ontology highlight
ABSTRACT:
SUBMITTER: Treger JS
PROVIDER: S-EPMC4167294 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Treger Jeremy S JS Priest Michael F MF Iezzi Raymond R Bezanilla Francisco F
Biophysical journal 20140901 6
Clinical methods used to assess the electrical activity of excitable cells are often limited by their poor spatial resolution or their invasiveness. One promising solution to this problem is to optically measure membrane potential using a voltage-sensitive dye, but thus far, none of these dyes have been available for human use. Here we report that indocyanine green (ICG), an infrared fluorescent dye with FDA approval as an intravenously administered contrast agent, is voltage-sensitive. The fluo ...[more]