Ontology highlight
ABSTRACT:
SUBMITTER: Kwon OJ
PROVIDER: S-EPMC4167399 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Kwon Oh-Joon OJ Valdez Joseph M JM Zhang Li L Zhang Boyu B Wei Xing X Su Qingtai Q Ittmann Michael M MM Creighton Chad J CJ Xin Li L
Nature communications 20140722
The prostate epithelial lineage hierarchy remains inadequately defined. Recent lineage-tracing studies have implied the existence of prostate luminal epithelial progenitors with extensive regenerative capacity. However, this capacity has not been demonstrated in prostate stem cell activity assays, probably owing to the strong susceptibility of luminal progenitors to anoikis. Here we show that constitutive expression of Notch1 intracellular domain impairs secretory function of mouse prostate lumi ...[more]