Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC4167631 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Zhang Zhao Z Wang Jie J Schultz Nadine N Zhang Fan F Parhad Swapnil S SS Tu Shikui S Vreven Thom T Zamore Phillip D PD Weng Zhiping Z Theurkauf William E WE
Cell 20140601 6
piRNAs guide an adaptive genome defense system that silences transposons during germline development. The Drosophila HP1 homolog Rhino is required for germline piRNA production. We show that Rhino binds specifically to the heterochromatic clusters that produce piRNA precursors, and that binding directly correlates with piRNA production. Rhino colocalizes to germline nuclear foci with Rai1/DXO-related protein Cuff and the DEAD box protein UAP56, which are also required for germline piRNA producti ...[more]