Asymmetric mRNA localization contributes to fidelity and sensitivity of spatially localized systems.

ABSTRACT: Although many proteins are localized after translation, asymmetric protein distribution is also achieved by translation after mRNA localization. Why are certain mRNA transported to a distal location and translated on-site? Here we undertake a systematic, genome-scale study of asymmetrically distributed protein and mRNA in mammalian cells. Our findings suggest that asymmetric protein distribution by mRNA localization enhances interaction fidelity and signaling sensitivity. Proteins synthesized at distal locations frequently contain intrinsically disordered segments. These regions are generally rich in assembly-promoting modules and are often regulated by post-translational modifications. Such proteins are tightly regulated but display distinct temporal dynamics upon stimulation with growth

SUBMITTER: Weatheritt RJ 

PROVIDER: S-EPMC4167633 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature