Interaction of fibronectin with semen amyloids synergistically enhances HIV infection.
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ABSTRACT:
SUBMITTER: Roan NR
PROVIDER: S-EPMC4168303 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Interaction of fibronectin with semen amyloids synergistically enhances HIV infection.
Roan Nadia R NR Chu Simon S Liu Haichuan H Neidleman Jason J Witkowska H Ewa HE Greene Warner C WC
The Journal of infectious diseases 20140408 7
Semen harbors amyloids that enhance human immunodeficiency virus type 1 (HIV-1) infection. We set out to identify factors that bind these amyloids and to determine whether these factors modulate amyloid-mediated HIV-enhancing activity. Using biochemical and mass spectrometric approaches, we identified fibronectin as a consistent interaction partner. Although monomeric fibronectin did not enhance HIV infection, it synergistically increased the infectivity enhancement activity of the amyloids. Dep ...[more]
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