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Estimation of recent and long-term malaria transmission in a population by antibody testing to multiple Plasmodium falciparum antigens.


ABSTRACT:

Background

Tools that estimate recent and long-term malaria transmission in a population would be highly useful for malaria elimination programs.

Methods

The prevalence of antibodies to 11 Plasmodium falciparum antigens was assessed by cytometric bead assay or enzyme-linked immunosorbent assay in 1000 people in a highland area of Kenya over 14 months, during a period of interrupted malaria transmission.

Results

Antibodies differed by antigen in acquisition with age: rapid (>80% antibody positive by age 20 years, 5 antigens), moderate (>40% positive by age 20 years, 3 antigens), or slow (<40% positive by age 20 years, 3 antigens). Antibody seroreversion rates in the 14 months between samples decreased with age rapidly (7 antigens), slowly (3 antigens), or remained high at all ages (schizont extract). Estimated antibody half-lives in individuals >10 years of age were long (40 to >80 years) for 5 antigens, moderate (5-20 years) for 3 antigens, and short (<1 year) for 3 antigens.

Conclusions

Antibodies to P. falciparum antigens in malaria-endemic areas vary by age, antigen, and time since last exposure to P. falciparum. Multiplex P. falciparum antibody testing could provide estimates of long-term and recent malaria transmission and potentially of a population's susceptibility to future clinical malaria.

SUBMITTER: Ondigo BN 

PROVIDER: S-EPMC4168304 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Publications

Estimation of recent and long-term malaria transmission in a population by antibody testing to multiple Plasmodium falciparum antigens.

Ondigo Bartholomew N BN   Hodges James S JS   Ireland Kathleen F KF   Magak Ng'wena G NG   Lanar David E DE   Dutta Sheetij S   Narum David L DL   Park Gregory S GS   Ofulla Ayub V AV   John Chandy C CC  

The Journal of infectious diseases 20140415 7


<h4>Background</h4>Tools that estimate recent and long-term malaria transmission in a population would be highly useful for malaria elimination programs.<h4>Methods</h4>The prevalence of antibodies to 11 Plasmodium falciparum antigens was assessed by cytometric bead assay or enzyme-linked immunosorbent assay in 1000 people in a highland area of Kenya over 14 months, during a period of interrupted malaria transmission.<h4>Results</h4>Antibodies differed by antigen in acquisition with age: rapid (  ...[more]

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