Dataset Information

Relationship between inflammation and infliximab pharmacokinetics in rheumatoid arthritis.

ABSTRACT: Infliximab, an anti-tumour necrosis factor-? monoclonal antibody, is indicated in rheumatoid arthritis (RA). Our objective was to evaluate the influence of the sources of infliximab pharmacokinetic variability in RA.Eighty-four patients treated with infliximab for RA were included in a prospective noncomparative study. They were analysed between two consecutive infliximab infusions. Infliximab concentrations were measured before the infusion, 2?h, 1 and 4 weeks after the infusion and immediately before the next infusion. Infliximab concentrations were described using a two-compartment population pharmacokinetic model.The mean (interindividual standard deviation) estimated central volume of distribution was 2.3?l (36%) and systemic clearance was 0.019?l?h(-1) (37%). The central volume of distribution increased with bodyweight; it was doubled between 50 and 90?kg. Systemic clearance increased with pre-infusion C-reactive protein concentration by 20%, varying from 3 to 14?mg?l(-) 1, and was decreased by 30% when methotrexate was coadministered.The influence of methotrexate and inflammation on infliximab clearance suggests that individual adjustment of infliximab doses according to disease activity may be useful in RA.

SUBMITTER: Ternant D

PROVIDER: S-EPMC4168386 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Relationship between inflammation and infliximab pharmacokinetics in rheumatoid arthritis.

Ternant David D Ducourau Emilie E Perdriger Aleth A Corondan Anca A Le Goff Benoît B Devauchelle-Pensec Valérie V Solau-Gervais Elisabeth E Watier Hervé H Goupille Philippe P Paintaud Gilles G Mulleman Denis D

British journal of clinical pharmacology 20140701 1

<h4>Aims</h4>Infliximab, an anti-tumour necrosis factor-α monoclonal antibody, is indicated in rheumatoid arthritis (RA). Our objective was to evaluate the influence of the sources of infliximab pharmacokinetic variability in RA.<h4>Methods</h4>Eighty-four patients treated with infliximab for RA were included in a prospective noncomparative study. They were analysed between two consecutive infliximab infusions. Infliximab concentrations were measured before the infusion, 2 h, 1 and 4 weeks after ...[more]

PMID: 24354889

Similar Datasets

Project description:IntroductionRheumatoid arthritis (RA) is a multifactorial autoimmune disease. Recently, growing evidence demonstrates that gut microbiota (GM) plays an important role in RA. But so far, no bibliometric studies pertaining to GM in RA have ever been published. This study attempts to depict the knowledge framework in this field from a holistic and systematic perspective based on the bibliometric analysis.MethodsLiterature related to the involvement of GM in RA was searched and picked from the Web of Science Core Collection (WOSCC) database. The annual output, cooperation, hotspots, research status and development trend of this field were analyzed by bibliometric software (VOSviewer and Bibliometricx).Results255 original research articles and 204 reviews were included in the analysis. The articles in this field that can be retrieved in WOSCC were first published in 2004 and increased year by year since then. 2013 is a growth explosion point. China and the United States are the countries with the most contributions, and Harvard University is the affiliation with the most output. Frontiers in Immunology (total citations = 603) is the journal with the most publications and the fastest growth rate. eLife is the journal with the most citations (total citations = 1248). Scher, Jose U. and Taneja, Veena are the most productive and cited authors. The research in this field is mainly distributed in the evidence, mechanism and practical application of GM participating in RA through the analysis of keywords and documents. There is sufficient evidence to prove the close relationship between GM and RA, which lays the foundation for this field. This extended two colorful and tender branches of mechanism research and application exploration, which have made some achievements but still have broad exploration space. Recently, the keywords "metabolites", "metabolomics", "acid", "b cells", "balance", "treg cells", "probiotic supplementation" appeared most frequently, which tells us that research on the mechanism of GM participating in RA and exploration of its application are the hotspots in recent years.DiscussionTaken together, these results provide a data-based and objective introduction to the GM participating in RA, giving readers a valuable reference to help guide future research.

Dataset Information

Relationship between inflammation and infliximab pharmacokinetics in rheumatoid arthritis.

Publications

Relationship between inflammation and infliximab pharmacokinetics in rheumatoid arthritis.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets