Ontology highlight
ABSTRACT:
SUBMITTER: Rublack N
PROVIDER: S-EPMC4168874 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Rublack Nico N Müller Sabine S
Beilstein journal of organic chemistry 20140815
Over the past 20 years, the generation of functional RNAs by in vitro selection has become a standard technique. Apart from aptamers for simple binding of defined ligands, also RNAs for catalysis of chemical reactions have been selected. In the latter case, a key step often is the conjugation of one of the two reactants to the library, requiring suitable strategies for terminal or internal RNA functionalization. With the aim of selecting a ribozyme for deamination of cytidine, we have set up a s ...[more]