Expeditive synthesis of trithiotriazine-cored glycoclusters and inhibition of Pseudomonas aeruginosa biofilm formation.
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ABSTRACT:
SUBMITTER: Smadhi M
PROVIDER: S-EPMC4168900 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Expeditive synthesis of trithiotriazine-cored glycoclusters and inhibition of Pseudomonas aeruginosa biofilm formation.
Smadhi Meriem M de Bentzmann Sophie S Imberty Anne A Gingras Marc M Abderrahim Raoudha R Goekjian Peter G PG
Beilstein journal of organic chemistry 20140825
Readily accessible, low-valency glycoclusters based on a triazine core bearing D-galactose and L-fucose epitopes are able to inhibit biofilm formation by Pseudomonas aeruginosa. These multivalent ligands are simple to synthesize, are highly soluble, and can be either homofunctional or heterofunctional. The galactose-decorated cluster shows good affinity for Pseudomonas aeruginosa lectin lecA. They are convenient biological probes for investigating the roles of lecA and lecB in biofilm formation. ...[more]
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