Dataset Information

A phase 2 study of 16?-[18F]-fluoro-17?-estradiol positron emission tomography (FES-PET) as a marker of hormone sensitivity in metastatic breast cancer (MBC).

ABSTRACT: PURPOSE:16?-[(18)F]-fluoro-17?-estradiol positron emission tomography (FES-PET) quantifies estrogen receptor (ER) expression in tumors and may provide diagnostic benefit. PROCEDURES:Women with newly diagnosed metastatic breast cancer (MBC) from an ER-positive primary tumor were imaged before starting endocrine therapy. FES uptake was evaluated qualitatively and quantitatively, and associated with response and with ER expression. RESULTS:Nineteen patients underwent FES imaging. Fifteen had a biopsy of a metastasis and 15 were evaluable for response. Five patients had quantitatively low FES uptake, six had at least one site of qualitatively FES-negative disease. All patients with an ER-negative biopsy had both low uptake and at least one site of FES-negative disease. Of response-evaluable patients, 2/2 with low FES standard uptake value tumors had progressive disease within 6 months, as did 2/3 with qualitatively FES-negative tumors. CONCLUSIONS:Low/absent FES uptake correlates with lack of ER expression. FES-positron emission tomography can help identify patients with endocrine resistant disease and safely measures ER in MBC.

SUBMITTER: Peterson LM

PROVIDER: S-EPMC4169237 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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A phase 2 study of 16α-[18F]-fluoro-17β-estradiol positron emission tomography (FES-PET) as a marker of hormone sensitivity in metastatic breast cancer (MBC).

Peterson Lanell M LM Kurland Brenda F BF Schubert Erin K EK Link Jeanne M JM Gadi V K VK Specht Jennifer M JM Eary Janet F JF Porter Peggy P Shankar Lalitha K LK Mankoff David A DA Linden Hannah M HM

Molecular imaging and biology 20131030 3

<h4>Purpose</h4>16α-[(18)F]-fluoro-17β-estradiol positron emission tomography (FES-PET) quantifies estrogen receptor (ER) expression in tumors and may provide diagnostic benefit.<h4>Procedures</h4>Women with newly diagnosed metastatic breast cancer (MBC) from an ER-positive primary tumor were imaged before starting endocrine therapy. FES uptake was evaluated qualitatively and quantitatively, and associated with response and with ER expression.<h4>Results</h4>Nineteen patients underwent FES imagi ...[more]

PMID: 24170452

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Dataset Information

A phase 2 study of 16?-[18F]-fluoro-17?-estradiol positron emission tomography (FES-PET) as a marker of hormone sensitivity in metastatic breast cancer (MBC).

Publications

A phase 2 study of 16α-[18F]-fluoro-17β-estradiol positron emission tomography (FES-PET) as a marker of hormone sensitivity in metastatic breast cancer (MBC).

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