Dataset Information

Thymidylate synthase genotype-directed chemotherapy for patients with gastric and gastroesophageal junction cancers.

ABSTRACT:

Background

Retrospective studies indicate associations between TSER (thymidylate synthase enhancer region) genotypes and clinical outcomes in patients receiving 5-FU based chemotherapy, but well-controlled prospective validation has been lacking.

Methods

In this phase II study (NCT00515216 registered through ClinicalTrials.gov, http://clinicaltrials.gov/show/NCT00515216), patients with "good risk" TSER genotypes (at least one TSER*2 allele) were treated with FOLFOX chemotherapy to determine whether prospective patient selection can improve overall response rates (ORR) in patients with gastric and gastroesophageal junction (GEJ) cancers, compared with historical outcomes in unselected patients (estimated 43%).

Results

The ORR in genotype-selected patients was 39.1% (9 partial responses out of 23 evaluable patients, 95% CI, 22.2 to 59.2), not achieving the primary objective of improving ORR. An encouraging disease control rate (DCR, consisting of partial responses and stable diseases) of 95.7% was noted and patients with homozygous TSER*2 genotype showed better tumor response.

Conclusions

In this first prospective, multi-institutional study in patients with gastric or GEJ cancers, selecting patients with at least one TSER*2 allele did not improve the ORR but led to an encouraging DCR. Further studies are needed to investigate the utility of selecting patients homozygous for the TSER*2 allele and additional genomic markers in improving clinical outcomes for patients with gastric and GEJ cancers.

Trial registration

ClinicalTrials.gov NCT00515216.

SUBMITTER: Goff LW

PROVIDER: S-EPMC4169411 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Thymidylate synthase genotype-directed chemotherapy for patients with gastric and gastroesophageal junction cancers.

Goff Laura W LW Thakkar Nilay N Du Liping L Chan Emily E Tan Benjamin R BR Cardin Dana B DB McLeod Howard L HL Berlin Jordan D JD Zehnbauer Barbara B Fournier Chloe C Picus Joel J Wang-Gillam Andrea A Lee Wooin W Lockhart A Craig AC

PloS one 20140918 9

<h4>Background</h4>Retrospective studies indicate associations between TSER (thymidylate synthase enhancer region) genotypes and clinical outcomes in patients receiving 5-FU based chemotherapy, but well-controlled prospective validation has been lacking.<h4>Methods</h4>In this phase II study (NCT00515216 registered through ClinicalTrials.gov, http://clinicaltrials.gov/show/NCT00515216), patients with "good risk" TSER genotypes (at least one TSER*2 allele) were treated with FOLFOX chemotherapy to ...[more]

PMID: 25232828

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Dataset Information

Thymidylate synthase genotype-directed chemotherapy for patients with gastric and gastroesophageal junction cancers.

Background

Methods

Results

Conclusions

Trial registration

Publications

Thymidylate synthase genotype-directed chemotherapy for patients with gastric and gastroesophageal junction cancers.

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