Ontology highlight
ABSTRACT:
SUBMITTER: Subramanian V
PROVIDER: S-EPMC4169463 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Subramanian V V Ramachandran S S Banan B B Bharat A A Wang X X Benshoff N N Kreisel D D Gelman A E AE Mohanakumar T T
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20140912 10
Immune responses against lung-associated self-antigens (self-Ags) are hypothesized to play a role in the development of chronic lung graft rejection. We determined whether immune responses to lung self-Ags, K-alpha-1-tubulin (Kα1T) and Collagen V (Col-V) in the absence of alloimmunity, could promote airway inflammation and fibrosis. Following syngeneic murine orthotopic lung transplantation (LTx) we administered antibodies (Abs) to either Kα1T or Col-V or in combination to both of these self-Ags ...[more]