Ontology highlight
ABSTRACT:
SUBMITTER: Brown AO
PROVIDER: S-EPMC4169480 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Brown Armand O AO Mann Beth B Gao Geli G Hankins Jane S JS Humann Jessica J Giardina Jonathan J Faverio Paola P Restrepo Marcos I MI Halade Ganesh V GV Mortensen Eric M EM Lindsey Merry L ML Hanes Martha M Happel Kyle I KI Nelson Steve S Bagby Gregory J GJ Lorent Jose A JA Cardinal Pablo P Granados Rosario R Esteban Andres A LeSaux Claude J CJ Tuomanen Elaine I EI Orihuela Carlos J CJ
PLoS pathogens 20140918 9
Hospitalization of the elderly for invasive pneumococcal disease is frequently accompanied by the occurrence of an adverse cardiac event; these are primarily new or worsened heart failure and cardiac arrhythmia. Herein, we describe previously unrecognized microscopic lesions (microlesions) formed within the myocardium of mice, rhesus macaques, and humans during bacteremic Streptococcus pneumoniae infection. In mice, invasive pneumococcal disease (IPD) severity correlated with levels of serum tro ...[more]