Ontology highlight
ABSTRACT:
SUBMITTER: Berry AA
PROVIDER: S-EPMC4169507 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Berry Andrea A AA Yang Yi Y Pakharukova Natalia N Garnett James A JA Lee Wei-chao WC Cota Ernesto E Marchant Jan J Roy Saumendra S Tuittila Minna M Liu Bing B Inman Keith G KG Ruiz-Perez Fernando F Mandomando Inacio I Nataro James P JP Zavialov Anton V AV Matthews Steve S
PLoS pathogens 20140918 9
Enteroaggregative Escherichia coli (EAEC) is a leading cause of acute and persistent diarrhea worldwide. A recently emerged Shiga-toxin-producing strain of EAEC resulted in significant mortality and morbidity due to progressive development of hemolytic-uremic syndrome. The attachment of EAEC to the human intestinal mucosa is mediated by aggregative adherence fimbria (AAF). Using X-ray crystallography and NMR structures, we present new atomic resolution insight into the structure of AAF variant I ...[more]