Genetic ancestry is associated with colorectal adenomas and adenocarcinomas in Latino populations.

ABSTRACT: Colorectal cancer rates in Latin American countries are less than half of those observed in the United States. Latin Americans are the resultant of generations of an admixture of Native American, European, and African individuals. The potential role of genetic admixture in colorectal carcinogenesis has not been examined. We evaluate the association of genetic ancestry with colorectal neoplasms in 190 adenocarcinomas, 113 sporadic adenomas and 243 age- and sex-matched controls enrolled in a multicentric case-control study in Colombia. Individual ancestral genetic fractions were estimated using the STRUCTURE software, based on allele frequencies and assuming three distinct population origins. We used the Illumina Cancer Panel to genotype 1,421 sparse single-nucleotide polymorphisms (SNPs), a

SUBMITTER: Hernandez-Suarez G 

PROVIDER: S-EPMC4169534 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature