Ontology highlight
ABSTRACT:
SUBMITTER: Miyazaki-Anzai S
PROVIDER: S-EPMC4169583 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Miyazaki-Anzai Shinobu S Masuda Masashi M Levi Moshe M Keenan Audrey L AL Miyazaki Makoto M
PloS one 20140919 9
Bile acid signaling is a critical regulator of glucose and energy metabolism, mainly through the nuclear receptor FXR and the G protein-coupled receptor TGR. The purpose of the present study was to investigate whether dual activation of FXR and TGR5 plays a significant role in the prevention of atherosclerosis progression. To evaluate the effects of bile acid signaling in atherogenesis, ApoE-/- mice and LDLR-/- mice were treated with an FXR/TGR5 dual agonist (INT-767). INT-767 treatment drastica ...[more]