Ontology highlight
ABSTRACT:
SUBMITTER: Umicevic Mirkov M
PROVIDER: S-EPMC4169706 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Umiċeviċ Mirkov Maša M Cui Jing J Vermeulen Sita H SH Stahl Eli A EA Toonen Erik J M EJ Makkinje Remco R RR Lee Annette T AT Huizinga Tom W J TW Allaart Renee R Barton Anne A Mariette Xavier X Miceli Corinne Richard CR Criswell Lindsey A LA Tak Paul P PP de Vries Niek N Saevarsdottir Saedis S Padyukov Leonid L Bridges S Louis SL van Schaardenburg Dirk-Jan DJ Jansen Tim L TL Dutmer Ellen A J EA van de Laar Mart A F J MA Barrera Pilar P Radstake Timothy R D J TR van Riel Piet L C M PL Scheffer Hans H Franke Barbara B Brunner Han G HG Plenge Robert M RM Gregersen Peter K PK Guchelaar Henk-Jan HJ Coenen Marieke J H MJ
Annals of the rheumatic diseases 20121211 8
<h4>Background</h4>Treatment strategies blocking tumour necrosis factor (anti-TNF) have proven very successful in patients with rheumatoid arthritis (RA). However, a significant subset of patients does not respond for unknown reasons. Currently, there are no means of identifying these patients before treatment. This study was aimed at identifying genetic factors predicting anti-TNF treatment outcome in patients with RA using a genome-wide association approach.<h4>Methods</h4>We conducted a multi ...[more]