The changing face of hypophosphatemic disorders in the FGF-23 era.
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ABSTRACT:
SUBMITTER: Lee JY
PROVIDER: S-EPMC4170520 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
The changing face of hypophosphatemic disorders in the FGF-23 era.
Pediatric endocrinology reviews : PER 20130601
In the past decade, research in genetic disorders of hypophosphatemia has significantly expanded our understanding of phosphate metabolism. X-linked hypophosphatemia (XLH) is the most common inherited form of rickets due to renal phosphate wasting. Recent understanding of the mechanisms of disease and role of fibroblast growth factor 23 (FGF-23) in XLH and other hypophosphatemic disorders have opened new potential therapeutic avenues. We will discuss the current standard of treatment for XLH as ...[more]
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