Cortical-striatal gene expression in neonatal hippocampal lesion (NVHL)-amplified cocaine sensitization.
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ABSTRACT:
SUBMITTER: Chambers RA
PROVIDER: S-EPMC4170677 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
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Cortical-striatal gene expression in neonatal hippocampal lesion (NVHL)-amplified cocaine sensitization.
Chambers R A RA McClintick J N JN Sentir A M AM Berg S A SA Runyan M M Choi K H KH Edenberg H J HJ
Genes, brain, and behavior 20130622 5
Cortical-striatal circuit dysfunction in mental illness may enhance addiction vulnerability. Neonatal ventral hippocampal lesions (NVHL) model this dual diagnosis causality by producing a schizophrenia syndrome with enhanced responsiveness to addictive drugs. Rat genome-wide microarrays containing >24 000 probesets were used to examine separate and co-occurring effects of NVHLs and cocaine sensitization (15 mg/kg/day × 5 days) on gene expression within medial prefrontal cortex (MPFC), nucleus ac ...[more]
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