Ontology highlight
ABSTRACT:
SUBMITTER: Reddy AS
PROVIDER: S-EPMC4170814 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Reddy A Srinivas AS Tan Zhi Z Zhang Shuxing S
Journal of chemical information and modeling 20140829 9
In drug discovery and development, the conventional "single drug, single target" concept has been shifted to "single drug, multiple targets"--a concept coined as polypharmacology. For studies in this emerging field, dedicated and high-quality databases of multitargeting ligands would be exceedingly beneficial. To this end, we conducted a comprehensive analysis of the structural and chemical/biological profiles of polypharmacological agents and present a Web-based database (Polypharma). All of th ...[more]