Ontology highlight
ABSTRACT:
SUBMITTER: Sellers ZM
PROVIDER: S-EPMC4170835 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 20121224 5
<h4>Background</h4>Left ventricular (LV) abnormalities have been reported in cystic fibrosis (CF); however, it remains unclear if loss of cystic fibrosis transmembrane conductance regulator (CFTR) function causes heart defects independent of lung disease.<h4>Methods</h4>Using gut-corrected F508del CFTR mutant mice (ΔF508), which do not develop human lung disease, we examined in vivo heart and aortic function via 2D transthoracic echocardiography and LV catheterization.<h4>Results</h4>ΔF508 mouse ...[more]