Ontology highlight
ABSTRACT:
SUBMITTER: Cea M
PROVIDER: S-EPMC4171085 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Cea Michele M Cagnetta Antonia A Gobbi Marco M Patrone Franco F Richardson Paul G PG Hideshima Teru T Anderson Kenneth C KC
Current pharmaceutical design 20130101 4
Multiple Myeloma (MM) is a common hematologic malignancy of plasma cells representing an excellent model of epigenomics dysregulation in human disease. Importantly, these findings, in addition to providing a better understanding of the underlying molecular changes leading to this malignance, furnish the basis for an innovative therapeutic approach. Histone deacetylase inhibitors (HDACIs), including Vorinostat and Panobinostat, represent a novel class of drugs targeting enzymes involved in epigen ...[more]