Ontology highlight
ABSTRACT:
SUBMITTER: Datta A
PROVIDER: S-EPMC4171602 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Datta Arpita A Loo Ser Yue SY Huang Baohua B Wong Lingkai L Tan Sheryl S L SS Tan Tuan Zea TZ Lee Soo-Chin SC Thiery Jean Paul JP Lim Yaw Chyn YC Yong Wei Peng WP Lam Yulin Y Kumar Alan Prem AP Yap Celestial T CT
Oncotarget 20140801 15
Triple-negative breast cancer (TNBC) is characterized by unique aggressive behavior and lack of targeted therapies. Among the various molecular subtypes of breast cancer, it was observed that TNBCs express elevated levels of sphingosine kinase 1 (SPHK1) compared to other breast tumor subtypes. High levels of SPHK1 gene expression correlated with poor overall and progression- free survival, as well as poor response to Doxorubicin-based treatment. Inhibition of SPHK1 was found to attenuate ERK1/2 ...[more]