Sex and the migraine brain.
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ABSTRACT:
SUBMITTER: Borsook D
PROVIDER: S-EPMC4171725 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
Sex and the migraine brain.
Borsook D D Erpelding N N Lebel A A Linnman C C Veggeberg R R Grant P E PE Buettner C C Becerra L L Burstein R R
Neurobiology of disease 20140321
The brain responds differently to environmental and internal signals that relate to the stage of development of neural systems. While genetic and epigenetic factors contribute to a premorbid state, hormonal fluctuations in women may alter the set point of migraine. The cyclic surges of gonadal hormones may directly alter neuronal, glial and astrocyte function throughout the brain. Estrogen is mainly excitatory and progesterone inhibitory on brain neuronal systems. These changes contribute to the ...[more]
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