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Ebola hemorrhagic Fever: novel biomarker correlates of clinical outcome.


ABSTRACT:

Background

Ebola hemorrhagic fever (EHF) outbreaks occur sporadically in Africa and result in high rates of death. The 2000-2001 outbreak of Sudan virus-associated EHF in the Gulu district of Uganda led to 425 cases, of which 216 were laboratory confirmed, making it the largest EHF outbreak on record. Serum specimens from this outbreak had been preserved in liquid nitrogen from the time of collection and were available for analysis.

Methods

Available samples were tested using a series of multiplex assays to measure the concentrations of 55 biomarkers. The data were analyzed to identify statistically significant associations between the tested biomarkers and hemorrhagic manifestations, viremia, and/or death.

Results

Death, hemorrhage, and viremia were independently associated with elevated levels of several chemokines and cytokines. Death and hemorrhage were associated with elevated thrombomodulin and ferritin levels. Hemorrhage was also associated with elevated levels of soluble intracellular adhesion molecule. Viremia was independently associated with elevated levels of tissue factor and tissue plasminogen activator. Finally, samples from nonfatal cases had higher levels of sCD40L.

Conclusions

These novel associations provide a better understanding of EHF pathophysiology and a starting point for researching new potential targets for therapeutic interventions.

SUBMITTER: McElroy AK 

PROVIDER: S-EPMC4172044 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Publications

Ebola hemorrhagic Fever: novel biomarker correlates of clinical outcome.

McElroy Anita K AK   Erickson Bobbie R BR   Flietstra Timothy D TD   Rollin Pierre E PE   Nichol Stuart T ST   Towner Jonathan S JS   Spiropoulou Christina F CF  

The Journal of infectious diseases 20140212 4


<h4>Background</h4>Ebola hemorrhagic fever (EHF) outbreaks occur sporadically in Africa and result in high rates of death. The 2000-2001 outbreak of Sudan virus-associated EHF in the Gulu district of Uganda led to 425 cases, of which 216 were laboratory confirmed, making it the largest EHF outbreak on record. Serum specimens from this outbreak had been preserved in liquid nitrogen from the time of collection and were available for analysis.<h4>Methods</h4>Available samples were tested using a se  ...[more]

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