Ontology highlight
ABSTRACT:
SUBMITTER: Kovacs M
PROVIDER: S-EPMC4172222 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Kovács Miklós M Németh Tamás T Jakus Zoltán Z Sitaru Cassian C Simon Edina E Futosi Krisztina K Botz Bálint B Helyes Zsuzsanna Z Lowell Clifford A CA Mócsai Attila A
The Journal of experimental medicine 20140915 10
Although Src family kinases participate in leukocyte function in vitro, such as integrin signal transduction, their role in inflammation in vivo is poorly understood. We show that Src family kinases play a critical role in myeloid cell-mediated in vivo inflammatory reactions. Mice lacking the Src family kinases Hck, Fgr, and Lyn in the hematopoietic compartment were completely protected from autoantibody-induced arthritis and skin blistering disease, as well as from the reverse passive Arthus re ...[more]