Alpha-synuclein repeat variants and survival in Parkinson's disease.
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ABSTRACT:
SUBMITTER: Chung SJ
PROVIDER: S-EPMC4172351 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
Alpha-synuclein repeat variants and survival in Parkinson's disease.
Chung Sun Ju SJ Biernacka Joanna M JM Armasu Sebastian M SM Anderson Kari K Frigerio Roberta R Aasly Jan O JO Annesi Grazia G Bentivoglio Anna Rita AR Brighina Laura L Chartier-Harlin Marie-Christine MC Goldwurm Stefano S Hadjigeorgiou Georgios G Jasinska-Myga Barbara B Jeon Beom Seok BS Kim Yun Joong YJ Krüger Rejko R Lesage Suzanne S Markopoulou Katerina K Mellick George G Morrison Karen E KE Puschmann Andreas A Tan Eng-King EK Crosiers David D Theuns Jessie J Van Broeckhoven Christine C Wirdefeldt Karin K Wszolek Zbigniew K ZK Elbaz Alexis A Maraganore Demetrius M DM
Movement disorders : official journal of the Movement Disorder Society 20140227 8
<h4>Objectives</h4>To determine whether α-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD).<h4>Methods</h4>Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival.<h4>Results</h4>Twenty-one sites c ...[more]
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