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Emotion regulation moderates the risk associated with the 5-HTT gene and stress in children.

ABSTRACT: Carrying a short allele in the serotonin transporter polymorphism (5-HTTLPR) while experiencing stressful environments is linked to elevated risk for depression. What might offset this risky combination of genes and environment? We hypothesized that individual-level factors may play a protective role. Specifically, we examined whether individuals' ability to decrease their stress responses via effective emotion regulation may be an important moderating factor and addressed this hypothesis in a socioeconomically diverse sample of 205 children aged 9-15 years. At-risk children (short-allele carriers in high-stress contexts) exhibited more depressive symptoms than other groups. Importantly, at-risk children who used effective emotion regulation did not exhibit increased depressive symptoms. These results have important implications for the basic science of understanding risk and resilience: in addition to genes and environment, individuals' agentic ability to self-regulate may need to be considered as a critical third factor. Given that emotion regulation is learnable, these results also have strong public-health implications.

SUBMITTER: Ford BQ

PROVIDER: S-EPMC4172506 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Emotion regulation moderates the risk associated with the 5-HTT gene and stress in children.

Ford Brett Q BQ Mauss Iris B IB Troy Allison S AS Smolen Andrew A Hankin Benjamin B

Emotion (Washington, D.C.) 20140526 5

Carrying a short allele in the serotonin transporter polymorphism (5-HTTLPR) while experiencing stressful environments is linked to elevated risk for depression. What might offset this risky combination of genes and environment? We hypothesized that individual-level factors may play a protective role. Specifically, we examined whether individuals' ability to decrease their stress responses via effective emotion regulation may be an important moderating factor and addressed this hypothesis in a s ...[more]

PMID: 24866526

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Project description:BackgroundMaintaining good mental health is important during a crisis. However, little attention has been given to how people achieve this, or how they evaluate emotions associated with stressors, such as the COVID-19 pandemic. This study aims to (1) investigate whether emotion regulation, in particular cognitive reappraisal and suppression, moderates the relationship between COVID-19 stress and general mental distress and (2) examine gender differences in the interrelations between COVID-19 stress, emotion regulation, and mental distress.MethodsData from a population in Norway (n = 1.225) were collected using a cross-sectional survey during the early months of the COVID-19 pandemic. Emotion regulation was measured using the Emotion Regulation Questionnaire Scale (ERQ), COVID-19 stress with the COVID-19 Stress Scale, and mental distress with the Patient Health Questionnaire 4 (PHQ-4). Moderation analyses were conducted using the PROCESS macro for SPSS.ResultsThere was a strong association between COVID-19 stress and general mental distress (r = 0.61). The moderation analyses showed substantial moderation effects of cognitive reappraisal and suppression on the relationship between COVID-19 stress and mental distress. Cognitive reappraisal served as a buffer (p = 0.001) and suppression (p = 0.002) exacerbated the relation between COVID-19 stress and mental distress. Men had higher scores of suppression (p < 0.001), and women had higher scores of cognitive reappraisal (p = 0.025). The buffering effect of cognitive reappraisal presented itself only in women (p < 0.001), while the exacerbation effect of suppression appeared only in men (p < 0.001).ConclusionThe current study suggests that COVID-19 pandemic-related stress is easier to deal with for those who have the tendency to cognitively reappraise. In contrast, suppression is associated with symptoms of depression and anxiety. The prevention of mental distress can be supported by guiding people about the importance of using healthy emotion regulation strategies, as well as helping them to become more aware of the way they interpret and regulate their emotions. Gender differences in emotion regulation suggest gender awareness, e.g., tailored programs for men and women.

Dataset Information

Emotion regulation moderates the risk associated with the 5-HTT gene and stress in children.

Publications

Emotion regulation moderates the risk associated with the 5-HTT gene and stress in children.

Similar Datasets

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