Ontology highlight
ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC4172578 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Wang Qishan Q Tian Feng F Pan Yuchun Y Buckler Edward S ES Zhang Zhiwu Z
PloS one 20140923 9
Genome-Wide Association Studies shed light on the identification of genes underlying human diseases and agriculturally important traits. This potential has been shadowed by false positive findings. The Mixed Linear Model (MLM) method is flexible enough to simultaneously incorporate population structure and cryptic relationships to reduce false positives. However, its intensive computational burden is prohibitive in practice, especially for large samples. The newly developed algorithm, FaST-LMM, ...[more]