3'-Deoxy-3'-[18F]-Fluorothymidine PET imaging reflects PI3K-mTOR-mediated pro-survival response to targeted therapy in colorectal cancer.
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ABSTRACT:
SUBMITTER: McKinley ET
PROVIDER: S-EPMC4172755 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
3'-Deoxy-3'-[18F]-Fluorothymidine PET imaging reflects PI3K-mTOR-mediated pro-survival response to targeted therapy in colorectal cancer.
McKinley Eliot T ET Zhao Ping P Coffey Robert J RJ Washington M Kay MK Manning H Charles HC
PloS one 20140923 9
Biomarkers that predict response to targeted therapy in oncology are an essential component of personalized medicine. In preclinical treatment response studies that featured models of wild-type KRAS or mutant BRAF colorectal cancer treated with either cetuximab or vemurafenib, respectively, we illustrate that [(18)F]-FLT PET, a non-invasive molecular imaging readout of thymidine salvage, closely reflects pro-survival responses to targeted therapy that are mediated by PI3K-mTOR activity. Activati ...[more]
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