Ontology highlight
ABSTRACT:
SUBMITTER: Bonnet J
PROVIDER: S-EPMC4173158 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Bonnet Jacques J Wang Chen-Yi CY Baptista Tiago T Vincent Stéphane D SD Hsiao Wei-Chun WC Stierle Matthieu M Kao Cheng-Fu CF Tora László L Devys Didier D
Genes & development 20140901 18
The SAGA (Spt-Ada-Gcn5 acetyltransferase) coactivator complex contains distinct chromatin-modifying activities and is recruited by DNA-bound activators to regulate the expression of a subset of genes. Surprisingly, recent studies revealed little overlap between genome-wide SAGA-binding profiles and changes in gene expression upon depletion of subunits of the complex. As indicators of SAGA recruitment on chromatin, we monitored in yeast and human cells the genome-wide distribution of histone H3K9 ...[more]