Ontology highlight
ABSTRACT:
SUBMITTER: Morawski M
PROVIDER: S-EPMC4173296 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Morawski Markus M Dityatev Alexander A Hartlage-Rübsamen Maike M Blosa Maren M Holzer Max M Flach Katharina K Pavlica Sanja S Dityateva Galina G Grosche Jens J Brückner Gert G Schachner Melitta M
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20141001 1654
Perineuronal nets (PNs) in the brains of tenascin-R-deficient (tn-r(-/-)) mice develop in temporal concordance with those of wild-type (tn-r(+/+)) mice. However, the histological appearance of PNs is abnormal in adult tn-r(-/-) mice. Here, we investigated whether similar defects are also seen in dissociated and organotypic cultures from hippocampus and forebrain of tn-r(-/-) mice and whether the structure of PNs could be normalized. In tn-r(-/-) cultures, accumulations of several extracellular m ...[more]