Ontology highlight
ABSTRACT:
SUBMITTER: Singer J
PROVIDER: S-EPMC4174294 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Singer Josef J Fazekas Judit J Wang Wei W Weichselbaumer Marlene M Matz Miroslawa M Mader Alexander A Steinfellner Willibald W Meitz Sarah S Mechtcheriakova Diana D Sobanov Yuri Y Willmann Michael M Stockner Thomas T Spillner Edzard E Kunert Renate R Jensen-Jarolim Erika E
Molecular cancer therapeutics 20140422 7
Passive immunotherapy with monoclonal antibodies represents a cornerstone of human anticancer therapies, but has not been established in veterinary medicine yet. As the tumor-associated antigen EGFR (ErbB-1) is highly conserved between humans and dogs, and considering the effectiveness of the anti-EGFR antibody cetuximab in human clinical oncology, we present here a "caninized" version of this antibody, can225IgG, for comparative oncology studies. Variable region genes of 225, the murine precurs ...[more]