Gamma delta T cells recognize haptens and mount a hapten-specific response.
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ABSTRACT:
SUBMITTER: Zeng X
PROVIDER: S-EPMC4174581 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
Gamma delta T cells recognize haptens and mount a hapten-specific response.
Zeng Xun X Meyer Christina C Huang Jun J Newell Evan W EW Kidd Brian A BA Wei Yu-Ling YL Chien Yueh-hsiu YH
eLife 20140925
The ability to recognize small organic molecules and chemical modifications of host molecules is an essential capability of the adaptive immune system, which until now was thought to be mediated mainly by B cell antigen receptors. Here we report that small molecules, such as cyanine 3 (Cy3), a synthetic fluorescent molecule, and 4-hydroxy-3-nitrophenylacetyl (NP), one of the most noted haptens, are γδ T cell antigens, recognized directly by specific γδ TCRs. Immunization with Cy3 conjugates indu ...[more]
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