Ontology highlight
ABSTRACT:
SUBMITTER: Bartness TJ
PROVIDER: S-EPMC4175185 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Bartness Timothy J TJ Liu Yang Y Shrestha Yogendra B YB Ryu Vitaly V
Frontiers in neuroendocrinology 20140413 4
White adipose tissue (WAT) is innervated by the sympathetic nervous system (SNS) and its activation is necessary for lipolysis. WAT parasympathetic innervation is not supported. Fully-executed SNS-norepinephrine (NE)-mediated WAT lipolysis is dependent on β-adrenoceptor stimulation ultimately hinging on hormone sensitive lipase and perilipin A phosphorylation. WAT sympathetic drive is appropriately measured electrophysiologically and neurochemically (NE turnover) in non-human animals and this dr ...[more]