Ontology highlight
ABSTRACT:
SUBMITTER: Psychoyos D
PROVIDER: S-EPMC4175447 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Psychoyos Delphine D Vinod K Yaragudri KY Cao Jin J Xie Shan S Hyson Richard L RL Wlodarczyk Bogdan B He Weimin W Cooper Thomas B TB Hungund Basalingappa L BL Finnell Richard H RH
Birth defects research. Part B, Developmental and reproductive toxicology 20120206 2
In utero exposure to tetrahydrocannabinol, the psychoactive component of marijuana, is associated with an increased risk for neurodevelopmental defects in the offspring by interfering with the functioning of the endocannabinoid (eCB) system. At the present time, it is not clearly known whether the eCB system is present before neurogenesis. Using an array of biochemical techniques, we analyzed the levels of CB1 receptors, eCBs (AEA and 2-AG), and the enzymes (NAPE-PLD, DAGLα, DAGLβ, MAGL, and FAA ...[more]