CD44 but not CD24 expression is related to poor prognosis in non-cardia adenocarcinoma of the stomach.

ABSTRACT:

Background

Recent studies have focused on the diagnostic and prognostic significance of CD24 and CD44 expression in human cancers. This study aimed to explore changes in CD44 and CD24 expression levels in patients with gastric cancer and to assess their prognostic values.

Methods

CD44 and CD24 expression levels were investigated immunohistochemically in tumor samples from 290 patients with non-cardia gastric adenocarcinoma, of whom 77 had paired adjacent normal gastric mucosa. CD24 and CD44 mRNA levels were determined by quantitative polymerase chain reaction in 34 patients. Serum anti-Helicobacter pylori IgG was detected by enzyme-linked immunosorbent assay. Relationships between CD44 and CD24 protein expression levels and tumor parameters were analyzed and their prognostic

SUBMITTER: Cao X 

PROVIDER: S-EPMC4175630 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature