Ontology highlight
ABSTRACT:
SUBMITTER: Ayala-Lujan JL
PROVIDER: S-EPMC4176022 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Ayala-Lujan Jorge Luis JL Vijayakumar Vidhya V Gong Mei M Smith Rachel R Santiago Araceli E AE Ruiz-Perez Fernando F
PloS one 20140924 9
The serine protease autotransporter from Enterobacteriaceae (SPATE) family, which number more than 25 proteases with apparent diverse functions, have been phylogenetically divided into two distinct classes, designated 1 and 2. We recently demonstrated that Pic and Tsh, two members of the class-2 SPATE family produced by intestinal and extraintestinal pathogenic E. coli, were able to cleave a number of O-glycosylated proteins on neutrophils and lymphocytes resulting in impaired leukocyte function ...[more]