Ontology highlight
ABSTRACT:
SUBMITTER: Kambara H
PROVIDER: S-EPMC4176326 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Kambara Hiroto H Niazi Farshad F Kostadinova Lenche L Moonka Dilip K DK Siegel Christopher T CT Post Anthony B AB Carnero Elena E Barriocanal Marina M Fortes Puri P Anthony Donald D DD Valadkhan Saba S
Nucleic acids research 20140813 16
Long non-coding RNAs (lncRNAs) play critical roles in diverse cellular processes; however, their involvement in many critical aspects of the immune response including the interferon (IFN) response remains poorly understood. To address this gap, we compared the global gene expression pattern of primary human hepatocytes before and at three time points after treatment with IFN-α. Among ∼ 200 IFN-induced lncRNAs, one transcript showed ∼ 100-fold induction. This RNA, which we named lncRNA-CMPK2, was ...[more]