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Antileishmanial metabolites from Geosmithia langdonii.

ABSTRACT: Antileishmanial bioassay guided fractionation of Geosmithia langdonii has resulted in the isolation and identification of two new compounds (1 and 2) together with 10 known compounds (3-12). The structures of the isolated metabolites were elucidated based on comprehensive 1D and 2D NMR spectroscopic data as well as mass spectrometry. The absolute configuration at C4, C5, and C6 of 2 was determined as R using a modified Mosher esterification method and NOESY correlations. The extracts and the isolated metabolites were evaluated for their antileishmanial activities. Compounds 3, 9, 11, and 12 were found to be active against Leishmania donovani with IC50 values of 6.9, 3.3, 8.5, and 9.2 ?M, respectively, while compounds 1, 5, and 10 showed lower activities against L. donovani with IC50 values of 13.0, 47.3, and 34.0 ?M, respectively.

SUBMITTER: Malak LG

PROVIDER: S-EPMC4176393 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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Antileishmanial metabolites from Geosmithia langdonii.

Malak Lourin G LG Ibrahim Mohamed Ali MA Bishay Daoud W DW Abdel-baky Afaf M AM Moharram Ahmed M AM Tekwani Babu B Cutler Stephen J SJ Ross Samir A SA

Journal of natural products 20140801 9

Antileishmanial bioassay guided fractionation of Geosmithia langdonii has resulted in the isolation and identification of two new compounds (1 and 2) together with 10 known compounds (3-12). The structures of the isolated metabolites were elucidated based on comprehensive 1D and 2D NMR spectroscopic data as well as mass spectrometry. The absolute configuration at C4, C5, and C6 of 2 was determined as R using a modified Mosher esterification method and NOESY correlations. The extracts and the iso ...[more]

PMID: 25084548

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