Ontology highlight
ABSTRACT:
SUBMITTER: Liegler T
PROVIDER: S-EPMC4176446 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Liegler Teri T Abdel-Mohsen Mohamed M Bentley L Gordon LG Atchison Robert R Schmidt Timothy T Javier Jacqueline J Mehrotra Megha M Eden Christopher C Glidden David V DV McMahan Vanessa V Anderson Peter L PL Li Peilin P Wong Joseph K JK Buchbinder Susan S Guanira Juan V JV Grant Robert M RM
The Journal of infectious diseases 20140416 8
<h4>Background</h4>The iPrEx study demonstrated that combination oral emtricitabine and tenofovir disoproxil fumarate (FTC/TDF) as preexposure prophylaxis (PrEP) protects against HIV acquisition in men who have sex with men and transgender women. Selection for drug resistance could offset PrEP benefits.<h4>Methods</h4>Phenotypic and genotypic clinical resistance assays characterized major drug resistant mutations. Minor variants with FTC/TDF mutations K65R, K70E, M184V/I were measured using 454 ...[more]