Ontology highlight
ABSTRACT:
SUBMITTER: Yin DM
PROVIDER: S-EPMC4176764 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Neuron 20130501 4
Neuregulin 1 (Nrg1) is a susceptibility gene of schizophrenia, a disabling mental illness that affects 1% of the general population. Here, we show that ctoNrg1 mice, which mimic high levels of NRG1 observed in forebrain regions of schizophrenic patients, exhibit behavioral deficits and hypofunction of glutamatergic and GABAergic pathways. Intriguingly, these deficits were diminished when NRG1 expression returned to normal in adult mice, suggesting that damage which occurred during development is ...[more]