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Neurobiology of aggression and violence.

ABSTRACT: Acts of violence account for an estimated 1.43 million deaths worldwide annually. While violence can occur in many contexts, individual acts of aggression account for the majority of instances. In some individuals, repetitive acts of aggression are grounded in an underlying neurobiological susceptibility that is just beginning to be understood. The failure of "top-down" control systems in the prefrontal cortex to modulate aggressive acts that are triggered by anger provoking stimuli appears to play an important role. An imbalance between prefrontal regulatory influences and hyper-responsivity of the amygdala and other limbic regions involved in affective evaluation are implicated. Insufficient serotonergic facilitation of "top-down" control, excessive catecholaminergic stimulation, and subcortical imbalances of glutamatergic/gabaminergic systems as well as pathology in neuropeptide systems involved in the regulation of affiliative behavior may contribute to abnormalities in this circuitry. Thus, pharmacological interventions such as mood stabilizers, which dampen limbic irritability, or selective serotonin reuptake inhibitors (SSRIs), which may enhance "top-down" control, as well as psychosocial interventions to develop alternative coping skills and reinforce reflective delays may be therapeutic.

SUBMITTER: Siever LJ

PROVIDER: S-EPMC4176893 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature

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Neurobiology of aggression and violence.

Siever Larry J LJ

The American journal of psychiatry 20080317 4

Acts of violence account for an estimated 1.43 million deaths worldwide annually. While violence can occur in many contexts, individual acts of aggression account for the majority of instances. In some individuals, repetitive acts of aggression are grounded in an underlying neurobiological susceptibility that is just beginning to be understood. The failure of "top-down" control systems in the prefrontal cortex to modulate aggressive acts that are triggered by anger provoking stimuli appears to p ...[more]

PMID: 18346997

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Project description:The present study aims at delineating violence from aggression, using genetically selected high (SAL, TA, NC900) and low (LAL, TNA NC100) aggressive mouse strains. Unlike aggression, violence lacks intrinsic control, environmental constraints as well as functional endpoints. Conventional measures namely latency, frequency and duration were used initially to accomplish the objective of delineation using the above strains. However, these quantitative measures fail to reveal further details beyond the magnitude of differential aggression, especially within the high aggressive mouse strains. Hence, it was necessary to analyze further, the behavioral sequences that make up the agonistic encounter. Novel measures such as threat/(attack + chase) (T/AC) and offense/withdrawal (O/W) ratios, context dependency and first-order Markov chain analysis were used for the above purpose. Our present analyses reveal clear qualitative behavioral differences between the three high aggressive selection strains based on the following facets namely structure and context in an agonistic interaction. Structure refers to a detailed study of the agonistic interaction components (ritualistic display, offense and sensitivity to the opponent submission cues) between any two subjects (inter-male interaction for the present study). Context refers to the capacity to identify an opponent by nature of its state (free moving/anesthetized), sex and the environment (home/neutral territory). NC900 displayed context dependency and structurally a rich repertoire of agonistic interaction components with an opponent. SAL failed to show discrimination and its inter-male agonistic behavior is restricted to a repetitive and an opponent-insensitive pattern of attack and chase. TA was comparable to SAL in terms of the structure but sensitive to context variables. Thus, SAL seems to display a violent form of aggressive behavior, while NC900 display 'functional' hyperaggression against a docile opponent in an inter-male agonistic interaction.

Project description:Bullying and sibling aggression can appear as similar behavior, though the latter is comparatively understudied. Aligned with the Theory of Intergenerational Transmission of Violence, research suggests that exposure to family violence increases an individual's risk for perpetrating violence in their own future relationships. Additionally, Problem Behavior Theory suggests that engaging in one problem behavior (e.g., bullying) increases the likelihood of engaging in other problem behavior (e.g., substance use). In Phase 1, this study of middle school students from the U.S. examined how exposure to family violence predicted membership in latent classes of bullying and sibling aggression perpetration (N = 894, sampled from four middle schools). In Phase 2, we used mixture modeling to understand how latent classes of family violence, sibling aggression, and bullying predict future substance use, mental health outcomes, and deviance behavior later in high school. Results yielded four profiles of peer and sibling aggression: high all, high sibling aggression, high peer aggression, and low all aggression. Youth who reported witnessing more family violence at home were significantly more likely to fall into the sibling aggression only and high all classes, compared to the low all class. Phase 2 results also yielded four classes: a high all class, a sibling aggression and family violence class, a peer aggression class, and a low all class. Individuals in the high all class were more likely to experience several unfavorable outcomes (substance use, depression, delinquency) compared to other classes. This study provides evidence for pathways from witnessing violence, to perpetrating aggression across multiple contexts, to developing other deleterious mental and behavioral health outcomes. These findings highlight the negative impact family violence can have on child development, providing support for a cross-contextual approach for programming aimed at developing relationships skills.

Dataset Information

Neurobiology of aggression and violence.

Publications

Neurobiology of aggression and violence.

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