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Chronic alcohol alters rewarded behaviors and striatal plasticity.

ABSTRACT: Chronic intermittent ethanol (CIE) alters neural functions and behaviors mediated by the dorsolateral striatum (DLS) and prefrontal cortex. Here, we examined the effects of prolonged (16-bout) CIE on DLS plasticity and DLS-mediated behaviors. Ex vivo electrophysiological recordings revealed loss in efficacy of DLS synaptically induced activation and absent long-term depression after CIE. CIE increased two-bottle choice drinking and impaired Pavlovian-to-instrumental transfer but not discriminated approach. These data suggest prolonged CIE impaired DLS plasticity, to produce associated changes in drinking and cue-controlled reward-seeking. Given recent evidence that less-prolonged CIE can promote certain dorsal striatal-mediated behaviors, CIE may drive chronicity-dependent adaptations in corticostriatal systems regulating behavior.

SUBMITTER: DePoy L

PROVIDER: S-EPMC4177024 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Chronic alcohol alters rewarded behaviors and striatal plasticity.

DePoy Lauren L Daut Rachel R Wright Tara T Camp Marguerite M Crowley Nicole N Noronha Bianca B Lovinger David D Holmes Andrew A

Addiction biology 20140326 2

Chronic intermittent ethanol (CIE) alters neural functions and behaviors mediated by the dorsolateral striatum (DLS) and prefrontal cortex. Here, we examined the effects of prolonged (16-bout) CIE on DLS plasticity and DLS-mediated behaviors. Ex vivo electrophysiological recordings revealed loss in efficacy of DLS synaptically induced activation and absent long-term depression after CIE. CIE increased two-bottle choice drinking and impaired Pavlovian-to-instrumental transfer but not discriminate ...[more]

PMID: 24666522

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